cant say if auto tune effective with mr12 but all my dyno mr12 tunes are set at 13.0/1 at all throttle positions. done several 10's this way, expect big gains in midrange, 8-12hp, and 8 up top with torque increase and much improved throttle response. this is spot on tuned, bike will rip. my tuner is primarily involved in high level roadracing and gets great results with mr12. do not add any timing at all with this fuel, if advanced pull it back out. very fast burn to produce max cylinder pressure does not work well with advanced timing. know this for a fact personally from experience. also pay attention to date of manufacture on can, it is the 3rd series of numbers under the mr12 designation. will read like 10516 which means made 105 day of 2016. unopened, no older than 6 mos, fresher better. expensive, but worth every penny at competition level to me. have to drain/flush fuel system after use, takes 5 min. get ur tune right, u will get the results ur seeking.